University of Groningen The bacterial sec machinery

Stepwise evolution of the Sec machinery in Proteobacteria.

The Sec machinery facilitates the translocation of proteins across and into biological membranes. In several of the Proteobacteria, this machinery contains accessory features that are not present in any other bacterial division. The genomic distribution of these features in the context of bacterial phylogeny suggests that the Sec machinery has evolved in discrete steps. The canonical Sec machin...

University of Groningen Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway Hutchins,

Dissimilar mechanistic background of peripheral and orofacial hyperkinesia in patients with Parkinson’s disease and levodopa-induced dyskinesia

Introduction: Long-term levodopa treatment of Parkinson’s disease (PD) is frequently complicated by spontaneously occurring involuntary muscle movements called dyskinesia. The exact pathological mechanism of this complication has not yet been elucidated. We have previously demonstrated that in PD patients the vulnerability to develop peripheral but not orofacial dyskinesia is associated w...

Controlling the activity of quorum sensing autoinducers with light† †Electronic supplementary information (ESI) available: Detailed experimental information on chemical synthesis, photoswitching experiments, bacterial growth conditions, bioluminescence assay, RNA isolation and cDNA synthesis, gene expression and pyocyanine assay details. See DOI: 10.1039/c5sc00215j

Title: Controlling the Activity of Quorum Sensing Autoinducers with Light Jan Pieter van der Berg,a§ Willem A. Velema,b§ Wiktor Szymanski,b,c Arnold J. M. Driessena* and Ben L. Feringab* aMolecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Nijenborgh 7, 9747 AG, Groningen, The Netherlands bCentre for Systems Chemistry, Stratingh Institute for Chemistry, Universi...

Adopting New International Health Instruments – What Can We Learn From the FCTC?; Comment on “The Legal Strength of International Health Instruments - What It Brings to Global Health Governance?”

This Commentary forms a response to Nikogosian’s and Kickbusch’s forward-looking perspective about the legal strength of international health instruments. Building on their arguments, in this commentary we consider what we can learn from the Framework Convention on Tobacco Control (FCTC) for the adoption of new legal international health instruments.